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HAIRY CELL LÖSEMİ (HCL) - VARIANT


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Medicine and Hematology Glossary

HAIRY CELL LÖSEMİ (HCL) - VARIANT

(Medicine and Hematology Glossary) :
Pek çok yönüyle klasik HCL'ye benzer. Varyant HCL'de de lösemik hücrelerde sitoplazmik villöz çıkıntılar vardır. Splenomegali saptanır. HCL'den farklı olarak, bu hücrelerde yuvarlak çekirdek içinde merkezsel yerleşimli, belirgin bir nükleolus bulunur. Yine HCL'den farklı olarak monositopeni yoktur, lökosit sayısı yüksektir. Tartarat Rezistan Asit Phosphatase (TRAP) ya negatiftir ya da zayıf pozitiftir. İnterferon-alfa tedavisine yanıt iyi değildir. Varyant hairy cell lenfositleri fenotipik olarak B-PLL ile hairy cell lenfositleri arasındaki bir aşamada yer alır.
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